7.2 Interleukin-17 (IL-17) secreting cells in synovial fluid express the "Th17" master transcription factor RORC and their numbers correlate with CCL20 levels within the joint
نویسندگان
چکیده
Background Th17 cells are a recently characterised, highly proinflammatory subset of T cells. We have shown that Th17 numbers are elevated in JIA synovial fluid and are significantly higher in extended than persistent oligoarthritis patients [1]. Interestingly we noted a high number of synovial T cells which produce both IL17 and interferon gamma (IFNγ). We also demonstrated that Th17 are actively recruited by the CCR6 ligand, CCL20, but the clinical relevance of this remained unclear.
منابع مشابه
Interleukin-17–producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers
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